![]() However, many neuronal circuits are brain-spanning, and access to whole-brain connectomes has been limited to a few small organisms, such as the nematode C. elegans, the larva of the fruit (or vinegar) fly, Drosophila melanogaster, and the tadpole larva of the tunicate Ciona intestinalis ( Ohyama et al., 2015, Ryan et al., 2016, White et al., 1986). Where available, neuronal “wiring diagrams” or “connectomes” ( Lichtman and Sanes, 2008)-maps of the synaptic connectivity between the neurons in a circuit-have proved extremely useful for understanding circuit function ( Ding et al., 2016, Jarrell et al., 2012, Kasthuri et al., 2015, Ohyama et al., 2015, Takemura et al., 2017b, Wanner et al., 2016). ![]() How brain circuits allow animals to implement complex behavior remains a central mystery of neurobiology.
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